Unique billing requirements create challenges for pathology practices, groups and labs. In order to successfully submit and collect on claims, billers and coders need to have in-depth knowledge of the sub-specialties in pathology, and they must have a current working knowledge of billing guidelines and updates about CPT codes for pathology services. With increasing scrutiny and tightening restrictions on laboratory billing practice management, it is imperative that clinical pathology labs implement stringent compliance procedures in accordance with changing laws and regulations.